For normal sized boards maybe, but both MSI and Gigabyte ITX boards aren't as well specified for both CPU and Ram overclocking, and like I mentioned I tried a Gigabyte one already and it is completely incompatible with my current ram.
I have a MSI itx build running 3800mhz ram. Was a simple click and go. Imo it's likely your ram causing the issue, but in reality idk what your setup is. So who knows.
The ram runs at 4000 MHz CL18 on two previous Asus boards.
It won't even boot at 3400 CL 16, and still blue screens at stock 3200 CL16 on my Gigabyte Z390.
Research into this is because other manufacturers motherboards only seem to handle overclocking 8 Gb sticks. Asus Optimem I and II seem to be the only way to fully overclock high density ram, as well as also being much better for overclocking 8 Gb sticks too.
However well your ram clocks on an MSI board, it will likely still do more on an Asus board with just 2 ram slots and Optimem II (currently Z490 ITX and Apex boards).
MSI / Gigabyte / Asrock specify their boards as default to have and work with 4 ram slots / modules. Asus boards with 2 slots specifically optimize having just two slots for vastly better memory overclocking.
You sound like an ASUS fanboi, and Idk where you're getting your info. Specs on my board support up to 4600mhz 4800mhz, and it only has 2 DIMM slots. I just think getting DDR4 at that speed is a waste of money seeing as DDR5 is on the horizon.
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