From the current study: >Zhang and colleagues have demonstrated that a shortened mRNA code of 675 base pairs could be loaded into phospholipid packets called **exosomes** derived from milk and then using that same milk, be fed to mice. The mice gastrointestinal tract absorbed the exosomes and the mRNA must have made it into the blood stream and lymphatic tissue because antibodies were produced in fed mice From a 2012 study: >Body fluid miRNA have been reported to exist in membrane vesicles such as microvesicles, **exosomes**, and apoptotic bodies (Simpson et al., 2009; Kosaka et al., 2010a). Exosomes have previously been reported to be present in milk (Admyre et al., 2007; Hata et al., 2010; Kosaka et al., 2010b; Reinhardt et al., 2012). **Our results suggest that milk miRNA are packaged in membrane vesicles, allowing them to avoid degradation in the infant gastrointestinal tract and to be absorbed in the intestine**. >**Based on this hypothesis, we suspected that milk RNA could resist the industrial manufacturing process**. In fact, Chen et al. (2010) proposed that some miRNA could be new standards for determining the quality of commercially available Chinese raw milk or milk-related products. >**Although all were detected in infant formulas, their levels were significantly lower in the extensively hydrolyzed formula than in the standard and follow-on formulas** Not sure how infant formulas are processed. Also: >Recently, it has been reported that **orally acquired exogenous plant miRNA are present in human and mouse sera and tissues**, and that these exogenous plant miRNA can regulate the expression of target genes in mammals https://www.sciencedirect.com/science/article/pii/S0022030212004973