MRna doesn’t misfold, it’s just instructions, it’s the proteins it instructs the body to make that can misfold Vaccine: >**Development of the messenger RNA (mRNA) vaccine** has emerged as an effective and speedy strategy to control the spread of new pathogens. After vaccination, the mRNA is translated into the real protein vaccine, and there is no need to manufacture the protein in vitro. **However, the fate of mRNA and its posttranslational modification inside the cell may affect immune response. Here, we showed that the mRNA vaccine of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with deletion of glycosites in the receptor-binding domain (RBD) or especially the subunit 2 (S2) domain to expose more conserved epitopes elicited stronger antibody and CD8+ T cell responses with broader protection against the alpha, beta, gamma, delta, and omicron variants, compared to the unmodified mRNA. Immunization of such mRNA resulted in accumulation of misfolded spike protein in the endoplasmic reticulum**, causing the up-regulation of BiP/GRP78, XBP1, and p-eIF2α to induce cell apoptosis and strong CD8+ T cell response. In addition, dendritic cells (DCs) incubated with S2-glysosite deleted mRNA vaccine increased class I major histocompatibility complex (MHC I) expression. This study provides a direction for the development of broad-spectrum mRNA vaccines which may not be achieved with the use of expressed proteins as antigens. https://pubmed.ncbi.nlm.nih.gov/35149556/ Here they’re trying to blame Covid and it’s spikes in a 2022 study. It would seem if you’re fully vaxxed and each shot contained roughly the same amount of mRna as you have cells in your body Covid, the Covid spikes from an infection would be the least of your worries. Imagine being injected twice(not counting boosters) with mRna which matches your total cells in your body each time, a lot of potential for misfolding. They seem to be trying to misdirect from the vax to blame Covid infections. >COVID-19 can affect a surprising number of organs in the body and can also result in longer-term health problems, or long COVID. The exact mechanism of these widespread effects is still unclear. **A buildup of abnormal proteins, called amyloidosis, is involved in other diseases that can cause similar symptoms to those of COVID-19, e.g., neurodegeneration or blood clots. Thus, it would be interesting to know whether parts of the SARS-CoV-2 spike protein can form such misfolded proteins, or amyloids**. >Sofie Nyström and Per Hammarström, Linköping University, Sweden, have investigated this issue. **The team looked at a library of different peptide fragments that could be created from the spike protein during an infection by enzymes involved in the body’s immune response. They then used assays of peptide mixtures, together with theoretical predictions, to identify peptides that are prone to form amyloids. The team found seven potentially amyloidogenic sequences within the sequence of the spike protein. Three of these peptides fulfilled all criteria for amyloid formation in the researcher’s experiments. One peptide, in particular, called Spike192, formed exceptionally well-ordered amyloid fibrils. Such fibrils could, for example, lead to hard-to-degrade micro blood clots involved in COVID-19 and long COVID**. Overall, the formation of amyloids from the spike protein could be important for understanding COVID-19 and long COVID.