"Keep out of reach of children less than 6 years of age" because you're not supposed to eat toothpaste and kids will eat a damn tube of toothpaste which will make them very extremely nauseous. You're not supposed to eat lotion or bleach. Similar labels are on household cleaning supplies. And about flouride: >While fluoride has been recommended for years, Hujoel's team wanted to focus on the intensity of oral hygiene to see if it made a difference in cavity prevention. They searched the published medical literature from 1950 to 2017 and found three randomized clinical trials, including 743 preteens and teens, that were sound enough to include and analyze. Follow-up ranged from about 2½ to 3 years. Two were conducted in the U.S. and one in England. None were funded by commercial companies. Researchers assigned children in the studies to an intense oral hygiene group or to a usual hygiene group of brushing and flossing. In the intense group in all three studies, the children had supervision of their oral hygiene, with plaque removal, at school, but no fluoride toothpaste was used at school. In the U.K. study, all used toothpaste with fluoride at home. Some in the U.S. studies used fluoride toothpaste and some did not at home, Hujoel says. While the design was not ideal, the key point was to compare intense hygiene with less intense hygiene, he says. Two studies were done in communities with nonfluoridated water supplies. "There was no significant difference in cavities between the groups," Hujoel says. "These intensive oral hygiene interventions, which were successful in removing the biofilm, did not have an impact on the cavities."