Thanks for your post, that was a good read. I have learned over the years that whenever I hear an opinion on a specific enough of an issue that has a high degree of certainty as part of the narrative that it is almost always wrong because: 1) The universe is messy and imprecise. 2) The universe seems to trend toward higher entropy and creating order (and therefore higher levels of precision) requires energy applied in very specific ways. Keeping that in mind makes all sorts of interesting accidents are incredibly likely regardless of how sure we are of our selves. I appreciate you posting about rna writing into dna a possibility, everyone seems so unbelievably sure this cannot happen. The other day Linus Torvalds posted a beautiful example of why leadership is difficult - he posted a set of propositions about mrna gene therapies and assumptions around them with such clarity and certainty that it is absolutely clear to anyone with even minor experience that he must be wrong. To anyone with even a slightly favourable view toward mrna based gene therapies he came across as gods word on the subject. It was really interesting to watch everyones response. I really like posts like yours because you speak about the probabilities of risk / reward and what can possibly happen in a way that matches observed reality. I enjoyed watching Brett and Pierre talking about this subject matter with a similarly balanced approach: https://www.youtube.com/watch?v=q01LUg97eto Thanks for your thoughts, please keep on posting.