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So there is a whole new class of therapy being developed. Instead of targeting receptors, they use gene therapy (using mRNA for example) to make the cell grow receptors that they can then target with what would otherwise be a totally benign compound. These are also called RASSLs - Receptor Activated Solely by Synthetic Ligands. So now it is theoretically possible to sneak mRNA into a shot and then later introduce a seemingly benign compound into the food supply.

So there is a whole new class of therapy being developed. Instead of targeting receptors, they use gene therapy (using mRNA for example) to make the cell grow receptors that they can then target with what would otherwise be a totally benign compound. These are also called RASSLs - Receptor Activated Solely by Synthetic Ligands. So now it is theoretically possible to sneak mRNA into a shot and then later introduce a seemingly benign compound into the food supply.

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[–] • 1 pt

Okay.

Something you need to understand about mRNA - it isn't DNA. It isn't turned on and off based on the type of cell and the stage of development and various other stimuli - it's what's produced from DNA once a gene is turned on. It's a "go", it's a template to be actively used to produce proteins. It does its job, making the cell produce proteins for a while, until it's caught by the various cleanup mechanisms in the cell.

When mRNA is inserted into the body using this new therapy, that's what it does; it's taken up by some random cells, and goes about producing proteins. It's not well controlled, and the proteins it produces also have a limited lifespan.

It is not, therefore, a vehicle for a long-term modification to humans, and a not-very-effective one for a short-term one.

"Gene therapy" is not mRNA. It's DNA, inserted using a viral vector. This can potentially target specific cell types, with the gene introduced only activating for those cells, with a much greater potential for use - and misuse. And it's not impossible that it's being surreptitiously added to these vaccines.

But when you talk about mRNA like it's modifying human genes you sound like an uneducated conspiracy theorist. Just fucking quit it. It's like the "adrenochrome" shit, which is obvious bullshit using a synthesizable molecule to discredit possible actual misbehavior. JUST FUCKING QUIT IT.

[–] [deleted] • 0 pt (edited )

Dude, mRNA is used in gene therapy. Reverse transcriptase is a thing that exists and mRNA payloads are used in many gene therapies. Yes there are also DNA gene therapies but if you go actually look into it, you'll find examples. Try reading an article before mouthing off and sounding like a retard. Midwit.

[–] • 0 pt

Mmm. Looks like retroviruses are indeed used in gene therapy. Retroviruses use RNA, and reverse transcriptase to convert the RNA to DNA. Note, however, that the RNA in the virus is not mRNA; it is structured differently in order to encode to proper DNA. mRNA can't be used for that, it has different termini.

So you're still being inaccurate in your claims.

[–] [deleted] • 0 pt (edited )

Epub 2019 Feb 19. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S Kowalski 1 , Arnab Rudra 2 , Lei Miao 1 , Daniel G Anderson 3 Affiliations expand PMID: 30846391 PMCID: PMC6453548 DOI: 10.1016/j.ymthe.2019.02.012 Free PMC article Abstract

mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.

Here, a paper which includes using mRNA for gene editing took me 30 seconds on pubmed

edit to add:

Also as for mRNA working as a template for reverse transcriptase, from an article on inuslin production: Reverse transcriptase has also been employed in insulin production. By inserting eukaryotic mRNA for insulin production along with reverse transcriptase into bacteria, the mRNA could be inserted into the prokaryote's genome