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Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice:
https://doi.org/10.1126/sciadv.abb2878 https://advances.sciencemag.org/content/6/35/eabb2878.full
used a scalpel, and a drug (6-hydroxydopamine (6-OHDA), a neurotoxin) to cure diabetes in mice, but the papers authors in interviews refer to botox as equivalent in their pop-science writups of that paper , not even one year old.
The authors preference for 6-OHDA vs using botox, a stronger more local neurotoxin, is probably a labor saving device.
Efficacy ??? 85% efficacy for surgery.
Only 15% (surgical denervation) and 27% (chemical denervation) of the animals progressed to diabetes compared with the 100% incidence in mice that underwent sham surgery or vehicle treatment
85% efficacy... good scalpel control in a mouse!
a search for papers that point back (cite) "https://doi.org/10.1126/sciadv.abb2878" in 5 months should yield about 4 other similar studies.
Those authors of that paper do other super advanced research related to a drug cure, and not a temp 6 month cure involving surgery.
They will not be revisiting that paper, but others are going forward with it.
85% overnight efficacy in mice.
For natural pool of genetically predisposed to type-2 diabetes, takes money and time but varieties of species exist. Even a normal livestock commerical breed of sheep can be induced into diabetes at a rate of 1 in 44 animals in one year, if all 44 sheep are allowed unfettered access to FRUCTOSE snacks, vs sucrose, for one year. (Fructose is sadly not detected well in blood by humans nor sheep, and triggers those genetically predisposed to catch diabetes) A faster way to get diabetes in a primate genetically predisposed to get it, without loading on fructose, is by blood transfusion from another diabetic primate, discovered in Italy in 1974 or so, though this fact rarely talked about or studied. Also humans crash dieting can get diabetes years earlier than normal, if genetically predisposed. Now, finally, some bold scientists re-prove diabetes from a blood transfusion :
Researchers transmitted diabetes from one mouse to another just by injecting the animals :
https://www.sciencemag.org/news/2017/08/could-diabetes-spread-mad-cow-disease
https://medicorx.com/new-study-finds-type-2-diabetes-may-be-transmissible/
That paper REFUSES to discuss human blood transfusion.... a political "hot potato". And yet, it is a FACT, a fucking FACT that some people can get type 2 diabetes from blood transfusions as shown in 1974.
May I point out that is a study on mice with a genetic predisposition toward autoimmune diabetes. The denervation is thought to modulate the immune response which damages the pancreas.
That is far different from the Type 2 diabetes pathology and I dont know why you would expect it to work on type 2.
"genetic predisposition"?
Diabetes, even in humans, is at its root, a genetic predisposition, per subject.
I see your quibble point though.... you seem to want to naysay all studies until they involve humans in front of you.
Of course to save money and time, many animal studies speed it up with animals designed to more readily be afflicted with disease being studied. You can buy a wide range of lab animals prone to certain conditions, with cancer animals being a major one.
In time, the papers citing diabetes surgery on aged rhesus macaques will appear, I predict, the gold standard animal, and large enough for precision surgeries.
Instead of forcing a selectively bred rhesus macaque pron to diabetes, it seems 9 out of 12 OBESE age 10 rhesus monkeys were naturally diabetic in one study, and raised in private cages. With a number as high as 9 in 12 seniors tilting to diabetes, it seems the darling animal of science, can be cheaply obtained by buying the supply of preexisting fat old monkeys, rather than waiting 10 years to appease you and your doubting.
I say that because you seem to be "species triggered" at the mice used in my first link. Natural occurring diabetes is high in old fat rhesus macaques, and provides ample test subjects to avoid a human trial to appease you. A human trial would also have to let the patient know that its only a 6 month cure anyways.
They used this RIP-LCMV-GP mouse, which they call a diabetes model. I assume its been engineered for type 1 predisposition. The point is type 1 and type 2 have different pathologies. I would think you might have more luck fucking around with the stomach or small intestines based on the results seen in gastric surgery. It would be nice to accomplish the same results without cutting out peoples stomachs.
(post is archived)