So what do you think of this hit-piece study on Ivermectin?

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I don't really need to think... I just need to actually read the study and have basic reading comprehension skills. The 'Findings' they articulate are not supported by the results they published:

Findings In this open-label randomized clinical trial of high-risk patients with COVID-19 in Malaysia, a 5-day course of oral ivermectin administered during the first week of illness did not reduce the risk of developing severe disease compared with standard of care alone.

That's the part they want you to read and what they want the headlines to be... BUT:

Results Among 490 patients included in the primary analysis (mean [SD] age, 62.5 [8.7] years; 267 women [54.5%]), 52 of 241 patients (21.6%) in the ivermectin group and 43 of 249 patients (17.3%) in the control group progressed to severe disease (relative risk [RR], 1.25; 95% CI, 0.87-1.80; P = .25). For all prespecified secondary outcomes, there were no significant differences between groups. Mechanical ventilation occurred in 4 (1.7%) vs 10 (4.0%) (RR, 0.41; 95% CI, 0.13-1.30; P = .17), intensive care unit admission in 6 (2.4%) vs 8 (3.2%) (RR, 0.78; 95% CI, 0.27-2.20; P = .79), and 28-day in-hospital death in 3 (1.2%) vs 10 (4.0%) (RR, 0.31; 95% CI, 0.09-1.11; P = .09). The most common adverse event reported was diarrhea (14 [5.8%] in the ivermectin group and 4 [1.6%] in the control group).

21.6% of the ivermectin progressed to severe disease
17.3% of the contol group progressed to severe disease

Hum... so what do they mean by 'severe disease'? What did this actually mean for patient outcomes?

Required Mechanical ventilation ivermectin: 1.7% Control: 4.0%

intensive care unit admission ivermectin: 2.4% Control: 3.2%

in-hospital death ivermectin: 1.2% Control: 4.0%

What?!?! The first line said there was no significant differnces but the ivermectin group is three time less likely to die and twice as likely to not need a ventilator! So where are these ivermectin patients that 'progressed to severe disease'? Its right there in the last line:

diarrhea ivermectin: 5.8% Control: 1.6%

So there it is folks. Even though it triples you survival chances you should not take it because you may get diarrhea

I don't really need to think... I just need to actually read the study and have basic reading comprehension skills. The 'Findings' they articulate are not supported by the results they published: > **Findings** In this open-label randomized clinical trial of high-risk patients with COVID-19 in Malaysia, a 5-day course of oral ivermectin administered during the first week of illness did not reduce the risk of developing severe disease compared with standard of care alone. That's the part they want you to read and what they want the headlines to be... **BUT:** > **Results** Among 490 patients included in the primary analysis (mean [SD] age, 62.5 [8.7] years; 267 women [54.5%]), 52 of 241 patients (21.6%) in the ivermectin group and 43 of 249 patients (17.3%) in the control group progressed to severe disease (relative risk [RR], 1.25; 95% CI, 0.87-1.80; P = .25). For all prespecified secondary outcomes, there were no significant differences between groups. Mechanical ventilation occurred in 4 (1.7%) vs 10 (4.0%) (RR, 0.41; 95% CI, 0.13-1.30; P = .17), intensive care unit admission in 6 (2.4%) vs 8 (3.2%) (RR, 0.78; 95% CI, 0.27-2.20; P = .79), and 28-day in-hospital death in 3 (1.2%) vs 10 (4.0%) (RR, 0.31; 95% CI, 0.09-1.11; P = .09). The most common adverse event reported was diarrhea (14 [5.8%] in the ivermectin group and 4 [1.6%] in the control group). - 21.6% of the ivermectin progressed to severe disease - 17.3% of the contol group progressed to severe disease Hum... so what do they mean by 'severe disease'? What did this actually mean for patient outcomes? **Required Mechanical ventilation** ivermectin: 1.7% Control: 4.0% **intensive care unit admission** ivermectin: 2.4% Control: 3.2% **in-hospital death** ivermectin: 1.2% Control: 4.0% What?!?! The first line said there was no significant differnces but the ivermectin group is three time less likely to die and twice as likely to not need a ventilator! So where are these ivermectin patients that 'progressed to severe disease'? Its right there in the last line: **diarrhea** ivermectin: 5.8% Control: 1.6% So there it is folks. Even though it triples you survival chances you should not take it because you may get diarrhea

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