I lived on opiates for a few years until I abandoned them. they were a pleasant escape. having been an addict, I can only speak from my experience. The constipation was the only negative effect . and mainly the reason I abandoned the narcotics. I like to test my will power and can I get addicted and then ditch my addiction. it sounds foolish but it empowers you. drugs, alcohol, it's all a test . embrace you fragility to die at any moment. you will eventually , whether you want to or not.