I have a mate who dated a chick with IBS and had most of her colon removed. She had a colostomy bag and a hole in her stomach that leads directly to her intestines. He really wanted children and one day we were discussing the pros and cons of settling down with this chick. She was a professional model, and super skinny mostly due to the fact that her body couldn't absorb nutrients. The cons were that her genetics were shit, and there was a large chance their children could have the same maladies. After a while of serious and earnest conversation, I tried to lighten the mood by saying "Well if you ever get tired of her regular holes, you could always try and fuck the colostomy hole." Dude was mortified. He is one of those people who were super liberal in his 20's and gone ultra white nationalist and conservative in his late 30's. Needless to say, he stopped wanting to hang out after that. Everytime I think back to that moment, I crack myself up and I know the joke was totally worth it.