On the whole I'd take it past age 50 or so. Maintains skeletal strength, help at the gym, keep your brain sharp and your dick good to go. I don't believe reasonable doses will affect the heart too much with a healthy lifestyle and those on trt live longer than those that don't, due to falls and breaks being more common that cvd. The average Olympian level body builder aka the guys on grams and grams of gear, including harsher compounds and orals, boat loads of insulin, hgh, diuretics and no doubt other shit too, live on average, longer than the average fat ass yank. That doesn't mean their healthy, but shows how truly unhealthy being unfit, obese(and its at least obese, not overweight) truly are. Reasonable dose of trt, no more than say 300 a week? Yeah, I'm gonna do it. When the time comes. If you want to start now, stick with safer compounds, like test, trest, masteron and primo. Orals aren't worth it. You might get acne or thinning hair.