I have no idea how pharmacokenetics translates from animals to humans but it looks like it has a half life of about half a day. That's relatively quick. For example, creatine has a half life of several days. Vitamin D also has a multi-day half life. So loading and maintenance is something you would do with them. My guess is it doesn't make sense to load Ivermectin especially if you don't see a pressing need for immediate benefit like exists sometimes with steroids where there is a pressing reason you are taking it right now. Even in anti-biotics which are taken for a pressing need and have a kinetics similar to Ivermectin loading is not really a practice. Now should you then take it thrice daily and consistently instead of with loading? I would suggest that knowing the mechanism of action and if it impacts sleep would be good things to know first. But consistent dosage seems more the ticket unless sleep is an issue or if it does its job effectively if there is at least one spike of it during the virus's incubation period. If so then consistency might not be that beneficial and may not be worth the impact to sleep. At which point you would take it in the morning with a consistent dose. Disclamer: I am not a doctor. I'm just capable of thinking through the basic logic of why pills are dosed the way they are.