Tell your wife to wear the mask, and constantly complain to her coworkers how lucky they are for being able to receive the vaccine and to thank them for accepting the vaccinate people like you're wife who have bad, potentially lethal reactions to the vaccines and therefore can't safely take them.
Change the narrative in their heads from, "She's a piece of shit for not doing something so simple." To, "We are heroes for protecting the vulnerable, like her, and it feels good to be appreciated."
In legal terms, your wife is fine. In practical terms...well, she'd never be explicitly fired for not get the shot. They'd wait until the third time she was late to work in a year and fire her for tardiness or something.
So your best bet is not standing on legality or logic and reasoning - if these people were logical or reasonable, Covid wouldn't be a thing. You need to be subtle and manipulate them.
This is definitely the best advice. These people use social manipulation techniques, so you need to play their game and fight back the same way. They typically skew towards the care/harm and fairness moral foundations (en.wikipedia.org), so appealing to those primarily is probably the way to go.
As depressing and enraging as it may be, this may be the best path for right now. She's literally getting pushed to tears in frustration over it. "Office politics" were already a bad enough thing in her department (but she stays because of some admittedly nice benefits and pay) before all this. Now it feels like our private business is of everyone else's concern.
I agree. Show up early, and never be late. If overtime is optional don't opt out.
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