I knew a girl that didn't have a sense of smell. The only difficulties she really told me about is that she'd have to have a friend to do a smell test when buying second hand furniture, and an funny story about a fire alarm.
She was woken up late at night by her fire alarm going off, and not seeing an actual fire she woke up her neighbors in her apartment building asking if they smelled anything, which they didn't. Fire department showed up and she had to explain that she had no sense of smell, and they were sceptical. They checked her apartment and found her roommate had left the oven on after cooking a pizza, and the heat going for hours eventually set off her fire alarm. She was horribly embarassed, but the firemen found it amusing.
I was worried about the ending but luckily it's a happy one.
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