I once worked a contract building a game that was an arcade game where it had a driving wheel, shift knob, pedals AND a joystick for controlling a turret. Needless to say the learning curve on controlling a 360 degree turret and firing it while driving around was pretty steep, but I can confirm it can be done. By the end of the project my co-workers were all pretty adept at doing it, but during the learning process we all crashed often.