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Link to the FDA medication guide.

Serious complications of ACAM2000 include: • Myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart). Most cases have occurred within 1-2 weeks after vaccination. Symptoms of myocarditis and pericarditis include: o Chest pain o Shortness of breath or difficulty breathing o Feelings of having a fast-beating, fluttering, or pounding heart Symptoms of myocarditis and pericarditis may be different in children and may also include: o Fainting o Unusual and persistent irritability o Unusual and persistent poor feeding o Unusual and persistent fatigue or lack of energy o Persistent vomiting o Persistent pain in the abdomen o Unusual and persistent cool, pale skin • Inflammation of the brain or spinal cord • Serious skin infections such as a rash caused by widespread infection of the skin (known as eczema vaccinatum), buildup of inflamed tissue around the vaccination site that may at first look like a bullseye and will grow into a large, non-healing sore (known as progressive vaccinia). • Spreading of the vaccine virus through the blood to other parts of your body • Fetal death • Accidental infection of the eye (which may cause swelling of the cornea causing watery painful eyes and blurred vision, scarring of the cornea, and blindness) • Severe allergic reaction after vaccination 2 The risks for serious vaccine side effects are greater for people who: • have heart problems or a history of heart problems • are taking steroid eye drops or ointment • have a weakened immune system • have skin problems such as eczema, atopic dermatitis, burns, impetigo, contact dermatitis, chickenpox, shingles, psoriasis, or uncontrolled acne • are less than 1 year old • are pregnant or become pregnant within 6 weeks after vaccination

Link to the FDA medication guide. >Serious complications of ACAM2000 include: • Myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart). Most cases have occurred within 1-2 weeks after vaccination. Symptoms of myocarditis and pericarditis include: o Chest pain o Shortness of breath or difficulty breathing o Feelings of having a fast-beating, fluttering, or pounding heart Symptoms of myocarditis and pericarditis may be different in children and may also include: o Fainting o Unusual and persistent irritability o Unusual and persistent poor feeding o Unusual and persistent fatigue or lack of energy o Persistent vomiting o Persistent pain in the abdomen o Unusual and persistent cool, pale skin • Inflammation of the brain or spinal cord • Serious skin infections such as a rash caused by widespread infection of the skin (known as eczema vaccinatum), buildup of inflamed tissue around the vaccination site that may at first look like a bullseye and will grow into a large, non-healing sore (known as progressive vaccinia). • Spreading of the vaccine virus through the blood to other parts of your body • Fetal death • Accidental infection of the eye (which may cause swelling of the cornea causing watery painful eyes and blurred vision, scarring of the cornea, and blindness) • Severe allergic reaction after vaccination 2 The risks for serious vaccine side effects are greater for people who: • have heart problems or a history of heart problems • are taking steroid eye drops or ointment • have a weakened immune system • have skin problems such as eczema, atopic dermatitis, burns, impetigo, contact dermatitis, chickenpox, shingles, psoriasis, or uncontrolled acne • are less than 1 year old • are pregnant or become pregnant within 6 weeks after vaccination