>. . . A group of German researchers tested for which specific antibody levels spike at what time. Specifically, they tested the Pfizer shot against the AstraZeneca shot and discovered something very concerning. Increasingly over time, and particularly with three doses of Pfizer, the immune response switched from the more neutralizing IgG1 and IgG3 antibodies to the non-neutralizing “tolerating” IgG4 antibodies: >High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors [emphasis added]. >Why is this so important? >Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2 [emphasis added]. >So not only do these shots fail to produce the first line of defense antibodies known as IgA in the mucosal, something we knew from day one, but even the blood-based antibodies are increasingly the wrong type. This problem seems to get worse over time and with more doses of the shot, which correlates perfectly with numerous studies showing negative efficacy increasing over time, with more doses, and how the vaccinated take longer to clear the virus. . . . more https://www.conservativereview.com/horowitz-possibly-the-most-important-study-on-covid-shots-might-explain-why-covid-never-seems-to-end-2659039644.html