[Wayback link](https://web.archive.org/web/20220429174417/https://arxiv.org/abs/2004.10177v7) >...there are ∼10[e+]632 mRNAs for the SARS-CoV-2 Spike protein... That answered a question I had. There are performance differences between the alternatives... >... our designs substantially improve mRNA half-life and protein expression in vitro, and dramatically increase antibody response by up to 23× in vivo, compared to the codon-optimized benchmark. It takes them 11 minutes of compute time to generate an mRNA design maybe starting from the desired protein. We are entering the age of chimeras.