Yes, the 1770s, when the Industrial Revolution abrogated evolutionary pressures that had hitherto governed life via the survival of the fittest and most adaptable. Instead, it fostered and an environment where those at the stagnant shallow end of the gene pool survived, bred and passed on their substandard and polluted legacies. 250ish years of this unfettered and irresponsible breeding has given rise to an ever growing horde of maladjusted misshapen miscreants that we find ourselves increasingly surrounded by.