I had something similar come up with a freckle on my shoulder. I had just turned 18, my mum was out of state, and the doctor told me we couldn't wait a week to get rid of it (it had angiogenesis - it was surrounded by this huge spider like mass of blood vessels that had come up within 1-2 days of me noticing the change in the freckle). He took it out then and there, a couple of stitches and a biopsy later - same thing as your wife. I am perfectly fine, haven't had any issues since. Getting rid of it fast is always the best option. Wishing you and your wife the best.