Vaccines affect different dogs different. A host that used to be on RBN has Great Danes that live to 14-15 because he doesn't give them any vaxx. He was saying at a party (years ago) one of the guests was sad because she just had to put hers down at 6 from cancer. She was amazed his were so old so she asked how. He said "no vaccines". She just gave him this dumb shocked look, didn't say another word and walked away ignoring him from then on.