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[–] 2 pts

The simple fact of bringing stuff from earth already carried germs, bacteria and microbes on Mars.

NASA goes to extreme lengths to make sure that doesn't happen.

https://planetaryprotection.jpl.nasa.gov/mission-implementation

[–] 1 pt

I know of this, but the earth atmosphere carries lots of these and they might have a tolerance where NASA knows, thinks or assumes that these living hitchhikers will die when they will travel in the vacuum of space.

[–] 1 pt

The exterior of the vehicle is not a concern as they're not going to survive atmospheric re-entry.

[–] 0 pt

I don't think unmanned payloads are 100% airtight to avoid concerns about (de)pressurization.