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In terms of academia, a source like Nature is considered La Creme de la Creme. If you can pick apart an academics argument using Nature as a reference then you've pretty much knocked a leg off of their 3 legged soap box.

The second exercise is understanding the terminology. Nature is good with terminology and reading it can sometimes be an exercise in understanding technobabble. You've got time, read it carefully and any expressions you don't understand look them up. If you are part of the master race then this is not above your intellect, but you may have to break down the expressions to make them more digestible. If you're finding it too hard to read then get gud scrub.

So, pop quiz: Based on current events and reading this review, tell me what issue you can spot from it. (Hint, it's mentioned in the introduction and and based around time periods.)

In terms of academia, a source like **Nature** is considered La Creme de la Creme. If you can pick apart an academics argument using Nature as a reference then you've pretty much knocked a leg off of their 3 legged soap box. The second exercise is understanding the terminology. Nature is good with terminology and reading it can sometimes be an exercise in understanding technobabble. You've got time, read it carefully and any expressions you don't understand look them up. If you are part of `the master race` then this is not above your intellect, but you may have to break down the expressions to make them more digestible. If you're finding it too hard to read then `get gud scrub`. So, pop quiz: Based on current events and reading this review, tell me what issue you can spot from it. (Hint, it's mentioned in the introduction and and based around time periods.)

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[–] • 0 pt

One thing I really dislike is that they're not objective. I can understand that people need to song and dance their ideas, touting them as the best thing since sliced bread for funding reasons - but it means they focus on the potential pros too much and maybe dedicate a short abridged line to the consequences, not properly philosophising the reason why there in a discussion.

[–] • 1 pt

Alot of this reads like an advertisement. They’re practically jerking off toward the end there.

But I did catch this:

However, recent human trials have demonstrated moderate and in rare cases severe injection site or systemic reactions for different mRNA platforms22,91. Potential safety concerns that are likely to be evaluated in future preclinical and clinical studies include local and systemic inflammation, the biodistribution and persistence of expressed immunogen, stimulation of auto-reactive antibodies and potential toxic effects of any non-native nucleotides and delivery system components. A possible concern could be that some mRNA-based vaccine platforms54,166 induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity167,168. Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken. Another potential safety issue could derive from the presence of extracellular RNA during mRNA vaccination. Extracellular naked RNA has been shown to increase the permeability of tightly packed endothelial cells and may thus contribute to oedema169. Another study showed that extracellular RNA promoted blood coagulation and pathological thrombus formation

Gee I didn’t see “let’s inject pregnant women and twelve year olds in there, eh? Also, I wonder if that extracellular RNA thrombus formation is going to be a thing? Has anyone heard anything about thrombus formation lately?

[–] • 0 pt

The thing that caught my eye was the double strand RNA (dsRNA), making me curious as to what effect they have drifting about.

But what you caught there could explain all the clots that have been forming?

[–] • 1 pt

Well potentially it promotes a type I interferon response which could promote inflamation and autoimmunity. Which I think is probably bad. I guess this PAMP thing is a resemblance to some double strand rna viruses.

Double strand viruses, wikipedia:

Since cells do not produce double-stranded RNA during normal nucleic acid metabolism, natural selection has favored the evolution of enzymes that destroy dsRNA on contact. The best known class of this type of enzymes is Dicer. It is hoped that broad-spectrum anti-virals could be synthesized that take advantage of this vulnerability of double-stranded RNA viruses.[14]

Dicer, wikipedia:

Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).

Also apparently free floating RNA is a signal to start clotting.