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I looked up anti gnrh antibodies to see what they are.
Second result was a .gov study saying a vaccine with them does not affect the reproductive systems of boars. (From 2016)
Two results lower is another .gov study saying they resulted in castrate levels of testosterone in prostate cancer patients. (From 2000)
So what I've taken from this 5 minute search is that anti gnrh antibodies destroy fertility and the government wants to use them in vaccines.
"anti gnrh antibodies sterility"
I found this:
>Immunization with GnRH resulted in decreased testicular size, drop of testosterone levels, and marked atrophy of the prostate. Anti-GnRH vaccine would be tried in patients of carcinoma of the prostate. LDH-C4, a sperm-specific mitochondrial antigen, produced an antibody response in baboons and reduced fertility in the females. Animal fertility control vaccines will be shortly on the market, but the use of recombinant DNA techniques should also accelerate the development of others.
https://pubmed.ncbi.nlm.nih.gov/2665354/
gonadotropin-releasing hormone (GnRH) agonists that were then in development for the treatment of prostate cancer in men, for their potential to suppress fertility in dogs (Tremblay & Belanger, 1984)...... Because of its mechanism of action of eliciting antibodies to GnRH which then suppressed testosterone production, not only did the vaccine decrease the prostate size of male dogs, but also suppressed fertility, although it never achieved regulatory approval for that use.
It seems pretty well documented that the anti gnrh antibodies decrease fertility in men, although I haven't dug into the data. It makes me wonder why a study in 2016 is even bothering studying the use in vaccines for boars.
They might have been thinking of using it for wild boar control in countries where they are a pest, e.g. Australia?
"It makes me wonder why a study in 2016 is even bothering studying the use in vaccines for boars."
My immediate thought was they're good at making bacon. (It's amazing how certain words can trigger the mind.)
I understand the use in prostate cancer treatment because they are trying to suppress the cancer growth and that is tied to the prostate and the hormones? This wouldn't be long-term? Though - most men who get prostate cancer are older and have already had children or decided not to, so there probably isn't a study on male fertility after prostate cancer treatment and recovery.
Yes I believe thats why they were researching it, and as you said most men with prostate cancer are older and fertility is not as big as a concern.
"I looked up anti gnrh antibodies to see what they are."
Sauce? Some links? Share the wealth.
I literally typed it into a search engine and that's it.
(post is archived)