Interesting indeed. (Had to look up 'dimerize'...been half a century since my last biochem class. ;-))
If you don't mind...what was your VOAT username?
Interesting indeed. (Had to look up 'dimerize'...been half a century since my last biochem class. ;-))
If you don't mind...what was your VOAT username?
Same name, I'm a creature of habit.
Nuclear receptors get complicated and highly specifical in a hurry. In general each one has a zinc finger motif that lets it recognize a short dna sequence, add so by having them mix and match into sets of two.. some things turn off, or turn on in a highly regulated manner.
Say, vitamin D + vitamin A receptor turns on YFP, while vitamin A+ Vitamin A only turns it off. Its complicated, and when it's out of balance, alternative pathways get activated that don't work as well. Combine a lifetime of neglect with a virus.... Yeah. It's an issue.
Same name, I'm a creature of habit.
Nuclear receptors get complicated and highly specifical in a hurry. In general each one has a zinc finger motif that lets it recognize a short dna sequence, add so by having them mix and match into sets of two.. some things turn off, or turn on in a highly regulated manner.
Say, vitamin D + vitamin A receptor turns on YFP, while vitamin A+ Vitamin A only turns it off. Its complicated, and when it's out of balance, alternative pathways get activated that don't work as well. Combine a lifetime of neglect with a virus.... Yeah. It's an issue.
(post is archived)