I've only done that when stringing pearls. I usually just use small beads in between bigger ones to break up a design when doing jewelry. When knotting between beads like with pearls the trick is to use a small pointed tool (looks like a tiny ice pick or a nail on a wood handle), slide the tip into the knot and position it exactly where you want it before pulling tight. When I tried to just tie them by hand and tighten the cord it ended up looking wonky because you can't get the knot in the precise distance between the pearls.
Good tip! I have bought pearl necklaces that aren't tied after each pearl and was threading a long string of plastic beads and someone else was doing the same but tying knots after each bead and I thought it was excessive effort, even if it will be handled by children mine would only ever be supervised so not worried about it breaking and being a choking hazard.
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