Considering the problems attributed to fructose, which has a very low glycemic index, I'm not so inclined to blame sugar per se. Many natural foods are quite sweet, and large meals, which seem to be something our ancestors consumed would also require insulin release. I think it is more likely the level of body fat that is the problem. I advocate both intermittent fasting of 16 hrs between meals, and avoiding snacking, even during the 8 hrs where you may be eating. I'd say, one meal a day is ideal.