The nucleus, where the DNA resides, is the fortified part of the cell - it is extremely difficult to bring stuff into it. There are viruses that do exactly that: Their RNA or DNA contains the blueprints to create proteins that not only enter the nucleus, these proteins also cut and replace parts of the DNA. But the mRNA vaccines are way too short to do such things, and they never enter the nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176331/ https://science.sciencemag.org/content/361/6407/1069.summary
This is about the RNA that is produced in the nucleus and not brought out correctly ("failure to remove ribonucleotides from DNA").
The RNA in the vaccine enters the nucleus of your cells and reconfigures them to produce viral antibodies that bind to the Ace2 receptors and block covid-19 from infecting cells. Thats how it acts as a prophylactic and trains the bodies immune system to recognize covid-19 from all of their own literature. So this RNA "vaccine" is entering the nucleus of your cells. Assuming they aren't just lying about whats actually in the vaccine. They could be using CRISPR to do other fun stuff because crisper itself is also just RNA.
No. Sorry, I don't want to be disrespectful, but this is not exact what happens.
RNA is produced in the nucleus, leaves the nucleus and is then used by protein factories as blueprints. Viruses use the same factories, their RNA let the factories produce proteins that are alien to the cell. When a cell detects that alien/viral material, it moves it to its surface and presents it to the cells of the immune system. The immune system learns to fight against the viral material by producing antibodies. Also, the immune system sends killer cells to destroy and eat the virus presenting cell as soon as possible (hopefully before viruses escape).
Vaccination mRNA does the same as virus RNA, but it is only the blueprint of a small part of the real virus (just the spike protein), so the immune system learns to create antibodies against the spike protein.
The nucleus is not involved in mRNA vaccines. It is involved in the AstraZeneca vaccine: They use a "living" virus that creates proteins that enter the nucleus and then create RNA there. This RNA then leaves the nucleus like RNA created by the cell. It also contains the blueprint of the spike protein.
But even the AZ vaccine does no "reconfiguration", the original mechanisms of the cell work unchanged. They just temporary trick a protein factory into using a blueprint that is not produced by the cell.
I see they are tricking some preexisting machinery outside of the nucleus of the cell to produce the spike proteins by introducing the foreign RNA inside the cell walls. They still are penetrating the cell wall with the RNA. It seems there is still a chance that the RNA can be uptake during mitosis though when the nucleus disassembles.
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