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It was clear “almost overnight” that the virus wasn’t human-made, Andersen says. Anyone hoping to create a virus would need to work with already known viruses and engineer them to have desired properties. But the SARS-CoV-2 virus has components that differ from those of previously known viruses, so they had to come from an unknown virus or viruses in nature. “Genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone,” Andersen and colleagues write in the study.

Oh, I see.... Because it's unknown to your bunch, it HAS to come from nature, I mean there's no fucking other way around, science is settled, proof

Non sequitur much?

>“This is not a virus somebody would have conceived of and cobbled together. It has too many distinct features, some of which are counterintuitive,” Garry says. “You wouldn’t do this if you were trying to make a more deadly virus.”

Yeah, so it just proves again it comes from nature, it certainly can't be obtained by luck in a lab, like fucking truckloads of corona strains mixed together just like nature would do through colonies of rodents, but just at a much faster pace you know

No that's impossible, who would do that

...

>Other scientists agree. “We see absolutely no evidence that the virus has been engineered or purposely released,”

Experts agree

They weren't there, but they know it all when it comes to chinese fuckeries in BSL4 labs

....

>Andersen’s group next set out to determine whether the virus could have been accidentally released from a lab. That’s a real possibility because researchers in many places are working with coronaviruses that have potential to infect humans, he says. “Stuff comes out of the lab sometimes, almost always accidentally,” he says. A couple of unexpected features of the virus caught the researchers’ eyes, Andersen says. In particular, the gene encoding the coronavirus’s spike protein has 12 extra RNA building blocks, or nucleotides, stuck in it.This spike protein protrudes from the virus’ surface and allows the virus to latch onto and enter human cells. That insertion of RNA building blocks adds four amino acids to the spike protein, and creates a site in the protein for an enzyme called furin to cut. Furin is made in human cells, and cleaves proteins only at spots where a particular combination of amino acids is found, like the one created by the insertion. SARS and other SARS-like viruses don’t have those cutting sites.Finding the furin cutting site was a surprise: “That was an aha moment and an uh-oh moment,” Garry says. When bird influenza viruses acquire the ability to be cut by furin, the viruses often become more easily transmissible. The insertion also created places where sugar molecules could be fastened to the spike protein, creating a shield to protect the virus from the immune system.The COVID-19 virus’ spike protein also binds more tightly to a protein on human cells called ACE2 than SARS does (SN: 3/10/20). Tighter binding may allow SARS-CoV-2 to more easily infect cells. Together, those features may account for why COVID-19 is so contagious (SN: 3/13/20).“It’s very peculiar, these two features,” Andersen says. “How do we explain how this came about? I’ve got to be honest. I was skeptical [that it was natural]. This could have happened in tissue culture” in a lab, where viruses may acquire mutations as they replicate many times in lab dishes. In nature, viruses carrying some of those mutations might be weeded out by natural selection but might persist in lab dishes where even feeble viruses don’t have to fight hard for survival.Clinching the case for nature But then the researchers compared SARS-CoV-2 with other coronaviruses recently found in nature, including in bats and pangolins. “It looks like SARS-CoV-2 could be a mix of bat and pangolin viruses,” Garry says.Viruses, especially RNA viruses such as coronaviruses, often swap genes in nature. Finding genes related to the pangolin viruses was especially reassuring because those viruses’ genetic makeup wasn’t known until after SARS-CoV-2’s discovery, making it unlikely anyone was working with them in a lab, he says.

COULD

UNLIKELY

Awesome

All this train of shit, starting with the premise that it could have escaped from a lab, ends up with a "clinching the case for nature", and a fucking "could" and "unlikely"

And that's their fucking demo right there, that's their fucking proof it wasn't lab made

Unbelievable

>In particular, pangolins also have the amino acids that cause the tight binding of the spike protein to ACE2, the team found. “So clearly, this is something that can happen in nature,” Andersen says. “I thought that was very important little clue. It shows there’s no mystery about its tighter binding to the human [protein] because pangolins do it, too." The sugar-attachment sites were another clue that the virus is natural, Andersen says. The sugars create a “mucin shield” that protects the virus from an immune system attack. But lab tissue culture dishes don’t have immune systems, making it unlikely that such an adaptation would arise from growing the virus in a lab. “That sort of explained away the tissue-culture hypothesis,” he says.Similarity of SARS-CoV-2 to bat and pangolin viruses is some of the best evidence that the virus is natural, Hodcroft says. “This was just another animal spillover into humans,” she says. “It’s really the most simple explanation for what we see.” Researchers still aren’t sure exactly which animal was the source. Andersen says the analysis probably won’t lay conspiracy theories to rest. Still, he thinks the analysis was worth doing. “I was myself skeptical at the beginning and I kept flipping back and forth,” Andersen says, but he’s now convinced. “All the data show it’s natural.”

Oh, I see... "this is something that can happen in nature", therefore not in a lab because dishes don't have immune systems, case closed!

And you know, it has to be done in dishes, because using animals, like fucking pangolins or fucking ferrets, no fucking way man! Again that's the proof, no dishes therefore nature! Because "unlikely" and "that sort of explained away" the tissue culture hypothesis

Brillant

"It’s really the most simple explanation for what we see" No shit, that has to be the most amateurish scientific investigation I have ever read claiming to have come up with definitive proof of anything

And the best part is that they aren't even sure which animal was the source after their pangolin certitude, again fucking brillant. Could it be ferrets why?

"I was myself skeptical at the beginning and I kept flipping back and forth" Oh yeah definitely, especially after the "clinching the case for nature" part when it comes to pangolins and no dishes therefore only nature can do that, I'm totally convinced

"but he’s now convinced. “All the data show it’s natural"

AHHAHAHAAH

Gofuckyourself andersen you fucken science nigger

**It was clear “almost overnight” that the virus wasn’t human-made, Andersen says. Anyone hoping to create a virus would need to work with already known viruses and engineer them to have desired properties.** **But the SARS-CoV-2 virus has components that differ from those of previously known viruses, so they had to come from an unknown virus or viruses in nature.** “Genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone,” Andersen and colleagues write in the study. Oh, I see.... Because it's unknown to your bunch, it HAS to come from nature, I mean there's no fucking other way around, science is settled, proof Non sequitur much? >>“This is not a virus somebody would have conceived of and cobbled together. It has too many distinct features, some of which are counterintuitive,” Garry says. “You wouldn’t do this if you were trying to make a more deadly virus.” Yeah, so it just proves again it comes from nature, it certainly can't be obtained by luck in a lab, like fucking truckloads of corona strains mixed together just like nature would do through colonies of rodents, but just at a much faster pace you know No that's impossible, who would do that ... >>Other scientists agree. “We see absolutely no evidence that the virus has been engineered or purposely released,” Experts agree They weren't there, but they know it all when it comes to chinese fuckeries in BSL4 labs .... >>**Andersen’s group next set out to determine whether the virus could have been accidentally released from a lab.** That’s a real possibility because researchers in many places are working with coronaviruses that have potential to infect humans, he says. “Stuff comes out of the lab sometimes, almost always accidentally,” he says. A couple of unexpected features of the virus caught the researchers’ eyes, Andersen says. In particular, the gene encoding the coronavirus’s spike protein has 12 extra RNA building blocks, or nucleotides, stuck in it.This spike protein protrudes from the virus’ surface and allows the virus to latch onto and enter human cells. That insertion of RNA building blocks adds four amino acids to the spike protein, and creates a site in the protein for an enzyme called furin to cut. Furin is made in human cells, and cleaves proteins only at spots where a particular combination of amino acids is found, like the one created by the insertion. SARS and other SARS-like viruses don’t have those cutting sites.Finding the furin cutting site was a surprise: “That was an aha moment and an uh-oh moment,” Garry says. When bird influenza viruses acquire the ability to be cut by furin, the viruses often become more easily transmissible. The insertion also created places where sugar molecules could be fastened to the spike protein, creating a shield to protect the virus from the immune system.The COVID-19 virus’ spike protein also binds more tightly to a protein on human cells called ACE2 than SARS does (SN: 3/10/20). Tighter binding may allow SARS-CoV-2 to more easily infect cells. Together, those features may account for why COVID-19 is so contagious (SN: 3/13/20).“It’s very peculiar, these two features,” Andersen says. “How do we explain how this came about? I’ve got to be honest. I was skeptical [that it was natural]. This could have happened in tissue culture” in a lab, where viruses may acquire mutations as they replicate many times in lab dishes. In nature, viruses carrying some of those mutations might be weeded out by natural selection but might persist in lab dishes where even feeble viruses don’t have to fight hard for survival.**Clinching the case for nature** But then the researchers compared SARS-CoV-2 with other coronaviruses recently found in nature, including in bats and pangolins. “**It looks like SARS-CoV-2 could be a mix of bat and pangolin viruses**,” Garry says.Viruses, especially RNA viruses such as coronaviruses, often swap genes in nature. Finding genes related to the pangolin viruses was especially reassuring because those viruses’ genetic makeup wasn’t known until after SARS-CoV-2’s discovery, making it **unlikely** anyone was working with them in a lab, he says. #COULD #UNLIKELY Awesome All this train of shit, starting with the premise that it could have escaped from a lab, ends up with a "clinching the case for nature", and a fucking "could" and "unlikely" And that's their fucking demo right there, that's their fucking proof it wasn't lab made Unbelievable >>In particular, **pangolins also have the amino acids that cause the tight binding of the spike protein to ACE2**, the team found. **“So clearly, this is something that can happen in nature**,” Andersen says. “I thought that was very important little clue. It shows there’s no mystery about its tighter binding to the human [protein] because pangolins do it, too." The sugar-attachment sites were another clue that the virus is natural, Andersen says. The sugars create a “mucin shield” that protects the virus from an immune system attack. **But lab tissue culture dishes don’t have immune systems**, making it **unlikely** that such an adaptation would arise from growing the virus in a lab. “That sort of explained away the tissue-culture hypothesis,” he says.**Similarity of SARS-CoV-2 to bat and pangolin viruses is some of the best evidence that the virus is natural**, Hodcroft says. “This was **just another animal spillover into humans**,” she says. “**It’s really the most simple explanation for what we see**.” **Researchers still aren’t sure exactly which animal was the source**. Andersen says the analysis probably won’t lay conspiracy theories to rest. Still, he thinks the analysis was worth doing. “I was myself skeptical at the beginning and I kept flipping back and forth,” Andersen says, **but he’s now convinced. “All the data show it’s natural**.” Oh, I see... "this is something that can happen in nature", therefore not in a lab because dishes don't have immune systems, case closed! And you know, it has to be done in dishes, because using animals, like fucking pangolins or fucking ferrets, no fucking way man! Again that's the proof, no dishes therefore nature! Because "unlikely" and "that sort of explained away" the tissue culture hypothesis Brillant "It’s really the most simple explanation for what we see" No shit, that has to be the most amateurish scientific investigation I have ever read claiming to have come up with definitive proof of anything And the best part is that they aren't even sure which animal was the source after their pangolin certitude, again fucking brillant. Could it be ferrets why? "I was myself skeptical at the beginning and I kept flipping back and forth" Oh yeah definitely, especially after the "clinching the case for nature" part when it comes to pangolins and no dishes therefore only nature can do that, I'm totally convinced "but he’s now convinced. “All the data show it’s natural" AHHAHAHAAH Gofuckyourself andersen you fucken science nigger

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