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Imagine a technology that could genetically rewire organisms in real-time, silencing critical genes across entire ecosystems with unknown effects. Sounds like science fiction? It’s not. It’s the reality of a new class of pesticides harnessing RNA interference—or RNAi—and they’re already being deployed in our fields and food supply with minimal testing or oversight. According to organic producers and non-GMO (genetically modified organisms) advocates, the risks could be catastrophic. . . RNAi works by using small RNA molecules to interfere with and “silence” the activity of specific genes. While that may sound precise, the FOE report emphasizes that RNAi technology is prone to “off-target effects,” meaning it can unintentionally silence genes in non-target organisms. Since many genes are conserved across species, a pesticide designed for one insect could end up harming beneficial pollinators, soil microbes, or even humans. What’s more, the alteration caused by RNAi can sometimes be passed down to future generations, meaning that a single application could spark uncontrollable ripple effects.

The Friends of the Earth report dubs RNAi pesticides “a vast, open-air genetic experiment,” with entire ecosystems at risk. Because they’re sprayed directly into the environment, controlling exposure is nearly impossible. Any organism that takes up the interfering RNAs could have its genome tinkered with. Some evidence suggests that ingesting RNAs from our diet may even influence human gene expression. . .

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>Imagine a technology that could genetically rewire organisms in real-time, silencing critical genes across entire ecosystems with unknown effects. Sounds like science fiction? It’s not. It’s the reality of a new class of pesticides harnessing RNA interference—or RNAi—and they’re already being deployed in our fields and food supply with minimal testing or oversight. According to organic producers and non-GMO (genetically modified organisms) advocates, the risks could be catastrophic. . . RNAi works by using small RNA molecules to interfere with and “silence” the activity of specific genes. While that may sound precise, the FOE report emphasizes that RNAi technology is prone to “off-target effects,” meaning it can unintentionally silence genes in non-target organisms. Since many genes are conserved across species, a pesticide designed for one insect could end up harming beneficial pollinators, soil microbes, or even humans. What’s more, the alteration caused by RNAi can sometimes be passed down to future generations, meaning that a single application could spark uncontrollable ripple effects. >The Friends of the Earth report dubs RNAi pesticides “a vast, open-air genetic experiment,” with entire ecosystems at risk. Because they’re sprayed directly into the environment, controlling exposure is nearly impossible. Any organism that takes up the interfering RNAs could have its genome tinkered with. Some evidence suggests that ingesting RNAs from our diet may even influence human gene expression. . . [Archive](https://archive.today/ozmqP)

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