You can explicitly disinherit your nephew and explicitly appoint a non-relative as your representative, e.g. a trusted friend. I can dig up the exact legal verbiage if you need it, since my own will has similar provisions.
Rather than disinherit someone you should leave them 20 bucks. That shows clear intent and they cannot contest it nearly as easily.
The purpose of explicitly disinheriting people is to ensure they don't get your residual estate by default if you and your beneficiaries die. e.g. my spouse and I have no children, so our beneficiaries are my spouse's siblings. It'd only take a family reunion and a freak car accident to take out all the named beneficiaries. To resolve that we'd either need a really lengthy list of backup beneficiaries, or just explicitly disinherit my douche canoe immediate family and say "IDGAF" after that.
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