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I was talking with my son about Ivermectin earlier today. I homeschooled him through the 7th grade, and during that time he (somehow!) learned to question "authority". So he doesn't trust the vaccine---but he doesn't trust anecdotal evidence re horse dewormer either.

Does anyone have anything remotely concrete that Ivermectin works (or doesn't)?

I was talking with my son about Ivermectin earlier today. I homeschooled him through the 7th grade, and during that time he (somehow!) learned to question "authority". So he doesn't trust the vaccine---but he doesn't trust anecdotal evidence re horse dewormer either. Does anyone have anything remotely concrete that Ivermectin works (or doesn't)?

(post is archived)

[–] 12 pts

There are a lot of studies cited, and linked, here: https://ivmmeta.com/

This site is basically a real time meta analysis of existing Ivermectin studies, it includes over 80 studies covering over 100,000 patients with an overall risk reduction of 63% [95%CI: 52‑71%], p < 0.0001 for early treatment. Yes, it is effective, but works best if given early, or even better as a prophylaxis, and in combination with other drugs and supplements, zinc being one of the most important.

Much of the negative press that Ivermectin has received has been the result of poorly designed studies (highly likely to be deliberately designed to fail), that give Ivermectin too late, in incorrect doses and without any combination. For example, studying Ivermectin in patients already hospitalized (due to cytokine storm) is practically pointless. The lead investigator of the Ivermectin arm of the RECOVERY trial in the UK admitted that there was a beneficial response to Ivermectin, but they stopped adding patients to that arm of the trial at a point designed to ensure that the benefit would not be "statistically significant", if they just kept adding more patients (as the original study design outlined), they would have got to a point where even that trial, which used a low dose given late in the disease progression, would have shown a statistically significant benefit.

Additionally, Ivermectin is a drug with a very well known safety profile, it has been used for many years both as a treatment and prophylaxis and is available over the counter in many countries. It is a drug that is basically safer than aspirin. So, even if it might not be as beneficial as it appears, the risk of using it is minimal, as is the cost.

You should be able to get down in the weeds of as many studies as you want from ivmmeta.com.