If you're planning on driving from Florida to California you should plan to spend a week just for driving otherwise you won't see much and it will just be a lot of non stop driving. I would recommend flying if at all possible to save time. For one day I wouldn't recommend going that far out of your way. As for places to see it really depends on how much time you have, how much money to budget and your transportation. You'd need a rental car or something for you to use while out here and plan your hotel stays around spots you want to focus on. For Southern California you really need to remember one key thing... The traffic is a crime against humanity... Don't expect to have a hotel in downtown Los Angeles and then drive around to San Diego or Santa Barbara for day trips. You'll end up spending most of your vacation here in a rental car sitting in traffic. I can go into more detail but I'd need something to go on to be specific otherwise I'd easily write a novel covering everything.