I am sure you can find synthesis papers for preferred best yield industrial process of C48 H74 O14 ,(22,23-dihydroavermectin) https://pubchem.ncbi.nlm.nih.gov/compound/Ivermectin-B1b You can buy a pure med grade canister of active compound powder from various vendors for far cheaper than synthesis old patents show best methods usually : Patents? 917 listed on that link above major chemical precursors but not the final drug (to north america) are on https://www.alibaba.com If you want it you just buy horse paste for your horse at a large farm supply store, but now they want to see a photo of you and your horse together, or want to see an agriculture license plate on your truck in the parking lot. **HCQ patents show EASY method of making HCQ, vs far more complex Ivermectin** All organic compounds create unwanted side products, the main sideproducts in HCQ are GRAS and part of the final pill, but the unwanted sideproducts in ivermectin could cause CANCER, NERVE DAMAGE, DEATH!!!!! organic chemistry is all about yields and purities.