If you have no background in real organic chemistry, you have no chance at producing Ivermectin at home. This is not a simple mixture of a few household ingredients. The fact that you are asking this question suggests you haven't done even the most basic research on what Ivermectin is in the first place. If you did, you would realize you need to start with a very specific bacteria that is only found in Japan.
The precursor chemicals agents that go into synthesizing Ivermectin come from letting the bacteria culture Streptomyces avermitilis ferment a base stock. This fermentation process will produce several organic compounds that are used in several process to produce hydrogenated versions of those compounds of which the ratiometric admixture 80:20 is the precursor compound 22,23-dihydroavermectin. Further chemical synthesis is needed to convert this avermectin into ivermectin. The processes are likely not going to be known widely and a garage chemist will not be able to do it without lots of equipment and reagents that they cannot get. So no, you can't make it at home.
Organic chemistry is not something you can just experiment with as a complete amateur. A home chemist will not be able to be assured of the purity of the results or even know for sure if they actually made ivermectin at all. You could easily produce products that will kill you dead and you won't even know the dangers. It can happen to professionals too, but that's why labs have controls and protocols for proper testing and analysis to prevent such mistakes. The equipment for that alone would break your piggy bank. The chemical reagents, as said, would likely get you red flagged and raided anyway. You can't just buy all the chemicals you want as a regular person. Even labs can't always buy whatever they want. There are reasons for that.
So yeah, call me a shill or whatever for speaking the cold hard truth of the matter, but your "simple" question has answers that are way bigger than you imagined. You can't do it. Most people can't do it. Don't even try because you are much more likely to produce a dangerous substance than one that will help you. And good luck getting that Japanese bacteria anyway.
What a great answer. I have no idea if any of that is true, but it sounds right.
Its all true, but one. There are very educated and experienced people that can do it in a larger home lab (at a farm), and I know some of those chemists. He did though stipulate:
MOST people can't do it
And I would even say MOST modern 2021 lower-standards college chemistry grads with just a BS and a normal range IQ can't do it properly, to my definition of "proper"
Even after synthesis and a pathetic yield (to ensure utmost purity), you need to wait 2 weeks for your toxicity studies of the batch in small mammals, including a sad LD-50 threshold test for an unfortunate rat. This chemical is forgiving and is non deadly up to 250x the normal dosage, so the LD-50 is for unknown byproduct revelation of your batch, and unknown purity of your batch. 250x cited : https://pubmed.ncbi.nlm.nih.gov/17234315/
He is right that no expert will hand a "loaded gun" to a uneducated novice, and will not cherry pick a "easy" old patent with a low yield that would be best for a home lab.
Jesus.
We have so much incredibly talent on our side. Thanks for taking the time to explain.
TIL
Streptomyces avermitilis Attc.org Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow
31267 $376
A lab to produce would be thousands of bucks, and access to contract labs for analysis. Not easy even if you know what you are doing.
I liked this.
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