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I've been looking for the answers to these questions for a while now and can't find anything good, especially to the second question (what Ivermectin is made from).

Does anyone out here know or have a resource on this?

I've been looking for the answers to these questions for a while now and can't find anything good, especially to the second question (what Ivermectin is made from). Does anyone out here know or have a resource on this?

(post is archived)

[–] 14 pts

If you have no background in real organic chemistry, you have no chance at producing Ivermectin at home. This is not a simple mixture of a few household ingredients. The fact that you are asking this question suggests you haven't done even the most basic research on what Ivermectin is in the first place. If you did, you would realize you need to start with a very specific bacteria that is only found in Japan.

The precursor chemicals agents that go into synthesizing Ivermectin come from letting the bacteria culture Streptomyces avermitilis ferment a base stock. This fermentation process will produce several organic compounds that are used in several process to produce hydrogenated versions of those compounds of which the ratiometric admixture 80:20 is the precursor compound 22,23-dihydroavermectin. Further chemical synthesis is needed to convert this avermectin into ivermectin. The processes are likely not going to be known widely and a garage chemist will not be able to do it without lots of equipment and reagents that they cannot get. So no, you can't make it at home.

Organic chemistry is not something you can just experiment with as a complete amateur. A home chemist will not be able to be assured of the purity of the results or even know for sure if they actually made ivermectin at all. You could easily produce products that will kill you dead and you won't even know the dangers. It can happen to professionals too, but that's why labs have controls and protocols for proper testing and analysis to prevent such mistakes. The equipment for that alone would break your piggy bank. The chemical reagents, as said, would likely get you red flagged and raided anyway. You can't just buy all the chemicals you want as a regular person. Even labs can't always buy whatever they want. There are reasons for that.

So yeah, call me a shill or whatever for speaking the cold hard truth of the matter, but your "simple" question has answers that are way bigger than you imagined. You can't do it. Most people can't do it. Don't even try because you are much more likely to produce a dangerous substance than one that will help you. And good luck getting that Japanese bacteria anyway.

[–] 3 pts

What a great answer. I have no idea if any of that is true, but it sounds right.

[–] 0 pt (edited )

Its all true, but one. There are very educated and experienced people that can do it in a larger home lab (at a farm), and I know some of those chemists. He did though stipulate:

MOST people can't do it

And I would even say MOST modern 2021 lower-standards college chemistry grads with just a BS and a normal range IQ can't do it properly, to my definition of "proper"

Even after synthesis and a pathetic yield (to ensure utmost purity), you need to wait 2 weeks for your toxicity studies of the batch in small mammals, including a sad LD-50 threshold test for an unfortunate rat. This chemical is forgiving and is non deadly up to 250x the normal dosage, so the LD-50 is for unknown byproduct revelation of your batch, and unknown purity of your batch. 250x cited : https://pubmed.ncbi.nlm.nih.gov/17234315/

He is right that no expert will hand a "loaded gun" to a uneducated novice, and will not cherry pick a "easy" old patent with a low yield that would be best for a home lab.

[–] 0 pt

Jesus.

We have so much incredibly talent on our side. Thanks for taking the time to explain.

TIL

[–] 2 pts

Streptomyces avermitilis Attc.org Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow

31267 $376

A lab to produce would be thousands of bucks, and access to contract labs for analysis. Not easy even if you know what you are doing.

[–] 5 pts

You' re better off making hcq or quinine which has been around for hundreds of years. There are many forms people make from quinine syrup to pills. Many online recipes. I also recommend getting a few herbal medicine books. Eventually normal meds may be hard to get so you need substitutions.

[–] 4 pts (edited )

I am sure you can find synthesis papers for preferred best yield industrial process of C48 H74 O14 ,(22,23-dihydroavermectin)

https://pubchem.ncbi.nlm.nih.gov/compound/Ivermectin-B1b

You can buy a pure med grade canister of active compound powder from various vendors for far cheaper than synthesis

old patents show best methods usually :

Patents? 917 listed on that link above

major chemical precursors but not the final drug (to north america) are on https://www.alibaba.com

If you want it you just buy horse paste for your horse at a large farm supply store, but now they want to see a photo of you and your horse together, or want to see an agriculture license plate on your truck in the parking lot.

HCQ patents show EASY method of making HCQ, vs far more complex Ivermectin

All organic compounds create unwanted side products, the main sideproducts in HCQ are GRAS and part of the final pill, but the unwanted sideproducts in ivermectin could cause CANCER, NERVE DAMAGE, DEATH!!!!!

organic chemistry is all about yields and purities.

[–] 0 pt

Whats to stop people from going to the pending zoo and getting a picture?

[–] 4 pts

Listen here you mother fuckers. I'm a Poal user. I live on a multi-thousand square mile property on a mountain that's surrounded my many more thousands of square miles of forest. I built my home myself. I cut all the lumber required and forged every metal component needed in my workshop.

My homestead is fully self sufficient. Livestock is butchered and preserved on-site and produce is a-plenty from the many gardens from which my wife creates home cooked meals everyday. My 20 children have been home-schooled and have only ever interacted with other kids from church.

If I want to make Ivermectin there's nothing that will stop me.

[–] 0 pt

How many meth labs blew up before you put all that together?

[–] 1 pt

making homemade drugs what could go wrong? even if you could you may need many controlled intermediate compounds that could get you red flagged for who knows what.

[–] 3 pts

Though I suspect you're not, you sound a bit like a shill here.

And you haven't answered the questions.

[–] 1 pt

by the time you even theoretically can make it how much more money would you have spent on lab equipment and chemicals than buying some from a vet

[–] 4 pts

Dude what is with you here?

Cost isn't a factor.

WHAT IS IT MADE FROM? HOW IS IT MADE?

[–] 0 pt

What a pathetic person you are. All medicines were homemade herbal concoctions for many thousands of years. Are you dumber than a caveman? Yes you are.

[–] 0 pt

You can make another anti parasitic. Wormwood, clove oil are good. Look up recipes on earth clinic or curezone for anti parasite cleanses. There's a really good brand clarkfx if you are going for something with similar effects to ivermectin.

[–] 1 pt

You can make another anti parasitic

Yes, but not all anti-parasitics work the same way. You could take another one that does not disrupt the mechanisms of the jewflu the way ivermectin does, but that doesn't give you the results you want.

Ethyl alcohol will get you drunk. If you drink another alcohol like methyl alcohol, well it would kill you. They are not the same.

[–] -1 pt

Wormwood

Wormwood is a proven powerful carcinogen, banned in over 40 nations many decades ago.

Anyway in thread I answer him

[–] 1 pt

You can buy it from India shipped through Canada, or get it with a prescription, delivered to your mailbox in 48 hours.

[–] 1 pt (edited )

There's a great, and true, story of a guy who wanted to synthesize some drug I can't recall now but it was something like cocaine I think. He found the process described in detail in a textbook in a University library, removed the pages and went home to set up his own lab. What he didn't understand was that it was very easy to accidentally also make a compound that results in Parkinson's.

Since he wasn't trained chemist and besides had no way of checking how pure the result was he ended up making a product that was heavily tainted with the bad compound. He developed a severe case of the illness and ended up taking his own life by ingesting an overdose of the drug he made, while propped up against a tree on the University grounds if I recall correctly.

There's a lesson here.

This was figured out after the fact by some guy who got curious about the incident and backtracked the fellow's steps, including locating the exact same reference book with the pages removed. It was all in a fascinating documentary I saw years ago. If I can find more details I'll come back and post them. And correct any errors I probably made.

[–] 1 pt

High Times did an article on synthesized coke back in the early 80's, with a warning that Parkinson's was a potential side effect.

I remember because some friends were experiencing numbness in their extremities after ingesting questionable stuff. Fortunately their issues subsided. But the admonition to know with certainty what you're taking has always stuck with me.

[–] 1 pt

I agree, it would be interesting to know more about it, even if making it yourself is beyond your expertise, scope and resources. Wikipedia says the following:

>The avermectin family of compounds was discovered by Satoshi Ōmura of Kitasato University and William Campbell of Merck. In 1970, Ōmura isolated unusual Streptomyces bacteria from the soil near a golf course along the south east coast of Honshu, Japan. Ōmura sent the bacteria to William Campbell, who showed that the bacterial culture could cure mice infected with the roundworm Heligmosomoides polygyrus. Campbell isolated the active compounds from the bacterial culture, naming them "avermectins" and the bacterium Streptomyces avermitilis for the compounds' ability to clear mice of worms (in Latin: a 'without', vermis 'worms'). Of the various avermectins, Campbell's group found the compound "avermectin B1" to be the most potent when taken orally. They synthesized modified forms of avermectin B1 to improve its pharmaceutical properties, eventually choosing a mixture of at least 80% 22,23-dihydroavermectin B1a and up to 20% 22,23-dihydroavermectin B1b, a combination they called "ivermectin"

[–] 0 pt

why bother, its 9$

Easier to just go liberate some from the back of a truck using a much more energetic organic molecule you can actually make on your own.

[–] 0 pt

99.9% of everyone will survive this cold without ivermectin, why not just buy a few doses for your family "just in case" it gets really bad for one of them and move on with your life? 2 full doses for the average size human is like $7.00