I'd say Fall/Winter of this year is when it really starts going bad. Vaccinated will start to drop as they cannot fight off the normal common cold, and as the weather turns freezing most of the civilized world will be much more dependent on supply chains and power to survive - which will be manipulated to demand further and more strict compliance with government directives before basic services/food is restored. We may even see deployment of military within USA (for our own good, of course). Their plans will not go well, of course, because they're stupid.