No. The gain of function research can be performed with monoclonal isolates, as they are called. Mainly, they are studying different variants of the S spike protein, which can also be generated in small isolates to study. The S spike protein can exist is a variety of different shapes. Think of it as a loosely coiled spring and different S spikes are wound tighter than others. Your body produces the CR3022 protein to fight off the S spike. By changing the shape of the spring, slightly, they were hoping to evade the body's defenses. The CR3023, in your body, is produced on a white blood cell polyprotein chain. In he lab, they do monoclonal isolates... just the piece of interest. However, the SARS COV 2 S spike turned out to fit too loosely to have any efficacy. This is why the pandemic failed to be an actual pandemic, if you believe SARS COV 2 is even real.