Technically, yes. James Madison, “father of the Constitution,” said as much, and Jefferson agreed. In practice, however, this proves more difficult, because USA Inc., as you put it, will likely fail to recognize the divorce, much like a sadistic wife, and will pursue a three pronged attack: demonization - claiming the abused state is actually the abuser, seduction - offering incentives to the people of the state to resist the decision to withdraw, and aggression - mounting a series of offensives meant to initially demoralize but ultimately defeat and even destroy the state if they refuse to remain.