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[–] 2 pts

Nicotine and tobacco are probably the least with opiates being the most.

[–] [deleted] 2 pts

Care to elaborate?

[–] 2 pts

Opiates have had the biggest detrimental effect on the west while nicotine and caffeine have had the least. In fact caffeine may be responsible for the enlightenment of humanity.

[–] 1 pt

I disagree that the nicotine has a low detriment level. Too many people gettin help to pay for their self inflicted cancer. Opiates are definitely one of the worst for sure. And caffeine is likely beneficial.